Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.
نویسندگان
چکیده
This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.
منابع مشابه
Systematic and site-specific analysis of N-sialoglycosylated proteins on the cell surface by integrating click chemistry and MS-based proteomics† †Electronic supplementary information (ESI) available: Supplementary text and references, six supplementary figures, and thirteen supplementary tables. See DOI: 10.1039/c5sc01124h Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
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Photoinduced single-crystal-to-single-crystal phase transition and photosalient effect of a gold(i) isocyanide complex with shortening of intermolecular aurophilic bonds† †Electronic supplementary information (ESI) available: X-ray crystallographic data, optical properties, DFT calculations, and other additional information. CCDC [987280 and 987281]. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02676d Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
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Triple aryne–tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles† †Electronic supplementary information (ESI) available: Experimental protocols, characterization data, X-ray crystallographic data (CIF) and NMR spectra of all new compounds. CCDC 1400529. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01726b Click here for additional data file. Click here for additional data file.
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